How to Keep Fruit Flies Forever Young: Stop the Protein Pileup in Their Brains! [SWOP NEWS]

**Scientists Reverse Brain Aging in Fruit Flies by Preventing F-Actin Buildup** Scientists have discovered a way to reverse brain aging in fruit flies by preventing the buildup of a common protein called filamentous actin (F-actin) in the brain. This buildup inhibits cellular recycling, leading to cognitive decline and overall health loss. By tweaking specific genes in aging fruit flies' neurons, researchers prevented F-actin buildup, maintained cellular recycling, and extended the healthy lifespan of fruit flies by approximately 30%. :


F-Actin Buildup:
F-actin forms filaments essential for cell structure and functions, but its accumulation in the brain inhibits cellular recycling and contributes to cognitive decline.

Correlation and Causality:
Initial observations showed that restricted diets and lifespan-extending drugs reduced F-actin buildup in aged flies. However, correlation was not enough to prove causality.

Genetic Intervention:
The researchers targeted the Fhos gene, which elongates and organizes actin filaments. Reducing Fhos expression in aging neurons prevented F-actin accumulation.

Improved Healthspan:
The genetic intervention improved overall health, extending lifespan by 25-30% and enhancing brain function and markers of health in other organ systems.

Cognitive Function:
Preventing F-actin accumulation protected cognitive function, as aged flies showed improved learning and memory.

Future Implications:
While these findings are promising, they have not yet been demonstrated in humans. However, they direct researchers toward new strategies for healthier aging in people, focusing on extending healthspan rather than just lifespan.

Conclusion:
This study offers hope for understanding and addressing age-related cognitive decline by targeting specific cellular mechanisms. While the results are promising, further research is needed to translate these findings into human interventions.

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